evidence

What if…

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Author Anna Luise Kirkengen
(#2 of the Whole Person reflections series)

What if one would weave a text by means of threads coloured by the recent topics of the on-going CauseHealth project. One thread would be causality, and how it is understood and applied in current biomedicine. Another would be ontology in the sense of how a human being and the human body is conceptualised in medicine and how this concept underpins the Western health care systems. A third thread would be methodology, and how the predominant methods for knowledge production, group based, randomised trials often including thousands of patients, might be radically challenged by the concept of N=1. A fourth thread would be stories in the sense of biographies before a person fell ill, and stories in the sense of testimonies of being ill – and how these have been systematically avoided as possible source of contamination in medical knowledge production. A fifth thread would then be knowledge condensates as these have grown both in number and normativity in the shape of clinical guidelines in all medical specialties during the latest years. Together, these threads can form quite different pictures, dependent on the frame applied. (more…)

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THE BEST EVIDENCE TENDS TO GET THE FACTS RIGHT

by Stephen Mumford, Better Evidence for a Better Healthcare Manifesto

Science is a normative enterprise, it should be acknowledged, and this applies just as much to medical research. We need to know how empirical knowledge should be gathered. What methods and techniques should we employ in order for our results to be considered scientific? Indeed, we can think of the term ‘scientific’ as an honorific bestowed upon certain claims when they have been discovered and substantiated in the right way. It is plausible that science is actually constituted by the set of norms for its proper conduct. (more…)

Evidence synthesis in pharmacology

By Elena Rocca

Pharmacology is a complex science that aims to balance harm and benefit of treatments for the individual patient. How should different types of evidence be synthesised in order to optimize this task? Should evidence from randomized trials be prioritized over other evidence, following the EBM model? If not, how can different types of evidence be amalgamated in an alternative way? (more…)